The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating
new insulin-producing cells from other cell types is a major aim of regenerative medicine …

Neuronal conversion from human fibroblasts can be induced by lineage-specific
transcription factors; however, the introduction of ectopic genes limits the therapeutic …

Cell replacement therapies for neurodegenerative disease have focused on transplantation
of the cell types affected by the pathological process. Here we describe an alternative …

When it comes to the epigenome, there is a fine line between clarity and confusion—walk
that line and you will discover another fascinating level of transcription control. With the …

The current diabetes mellitus pandemic constitutes an important global health problem.
Reductions in the mass and function of β-cells contribute to most of the pathophysiology …

Generation of surrogate β-cells is the need of the day to compensate the short supply of
islets for transplantation to diabetic patients requiring daily shots of insulin. Over the years …

Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific
cells for numerous applications. However, conversion across germ-layer borders often …

Developing cell-based diabetes therapies requires examining transcriptional mechanisms
underlying human β cell development. However, increased knowledge is hampered by low …