Protein–protein interactions (PPIs) are fundamental to many biological processes that play
an important role in the occurrence and development of a variety of diseases. Targeting the …

Norcantharidin (NCTD), a demethylated derivative of cantharidin, is an anticancer active
component in traditional Chinese medicine. At present, the main methods for finding its …

Abnormal Krüppel-like factor 11 (KLF11) expression is frequently found in tumor tissues and
is associated with cancer prognosis, but its biological functions and corresponding …

Mouse double minute 2 homolog (MDM2) is an E3 ubiquitin‐protein ligase that is involved in
the transfer of ubiquitin to p53 and other protein substrates. The expression of MDM2 is …

TP53 codes tumor protein 53-p53 that controls the cell cycle through binding DNA directly
and induces reversible cell-cycle arrest. The protein activates DNA repair genes if mutated …

The term" undruggable" is to describe molecules that are not targetable or at least hard to
target pharmacologically. Unfortunately, some targets with potent oncogenic activity fall into …

The term “undruggable” is to describe molecules that are not targetable or at least hard to
target pharmacologically. Unfortunately, some targets with potent oncogenic activity fall into …