If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Bacteria come in a range of shapes, including round, rod-shaped, curved and spiral cells.
This morphological diversity implies that different mechanisms exist to guide proper cell …

The formation of biomolecular condensates mediated by a coupling of associative and
segregative phase transitions plays a critical role in controlling diverse cellular functions in …

In most bacteria, chromosome segregation is driven by the ParAB S system where the
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …

The ParAB S system is essential for prokaryotic chromosome segregation. After loading at
parS on the genome, ParB (partition protein B) proteins rapidly redistribute to distances of …

The bacterial chromosome must be compacted more than 1,000-fold to fit into the
compartment in which it resides. How it is condensed, organized and ultimately segregated …

SMC condensin complexes play a central role in compacting and resolving replicated
chromosomes in virtually all organisms, yet how they accomplish this remains elusive. In …

Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus
genome by combining genome-wide chromatin interaction detection, live-cell imaging, and …

The widely conserved ParABS system plays a major role in bacterial chromosome
segregation. How the components of this system work together to generate translocation …