A plethora of innovative alternatives to keratoplasty for endothelial disease is in
development. Among these, surgical methods are still the mainstay of treatment and closest …

Delivery of RNA using nanomaterials has emerged as a new modality to expand therapeutic
applications in biomedical research. However, the delivery of RNA presents unique …

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein
(Cas)(CRISPR/Cas) systems have recently emerged as powerful molecular biosensing tools …

Lamellar ichthyosis (LI) is a chronic disease, mostly caused by mutations in the TGM1 gene,
marked by impaired skin barrier formation. No definitive therapies are available, and current …

Conspectus In human cells, intracellular access and therapeutic cargo transport, including
gene-editing tools (eg, CRISPR–Cas9 and transposons), nucleic acids (eg, DNA, mRNA …

Engineering the spatial organisation of organotypic cultures is pivotal for refining tissue
models that are useful for gaining deeper insights into complex, non‐cell autonomous …

Human corneal endothelial cells are organized in a tight mosaic of hexagonal cells and
serve a critical function in maintaining corneal hydration and clear vision. Regeneration of …

Tissue engineering and wound-healing interventions are often designed for use in diseased
and inflamed environments. In this space, endothelial cells (ECs) are crucial regulators of …

We describe in this work an evaluation of bundles of hollow mesoporous silicon nanotubes
to facilitate transfection of HeLa cells using small interfering RNA designed to knock down …

A plethora of innovative cell-based regenerative therapies for corneal diseases have been
developed in past years. While recent literature solidifies our knowledge, most studies are …