Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

Background & Aims: Until now, the basic matrix-producing cell type responsible for pancreas
fibrosis has not been identified. In this report, retinoid-containing pancreatic stellate cells …

Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to
collagen accumulation during chronic liver disease. With increasing interest in developing …

Hepatic fibrosis is a common response to chronic liver injury from many causes, including
alcohol, persistent viral and helminthic infections, and hereditary metal overload. Emerging …

The hepatic sinusoid harbors 4 different cells: endothelial cells (100, 101), Kupffer cells (96,
102, 103), fat-storing cells (34, 51, 93), and pit cells (14, 107. 108). Each cell type has its …

A consistent response to liver injury is the activation of resident mesenchymal cells known
as lipocytes (Ito, fat-storing cells) into a proliferating cell type. In cultured lipocytes, platelet …

Interferon gamma (IFN‐γ) inhibits in vitro the activation of hepatic stellate cells (HSC), the
primary extracellular matrix‐producing cells in liver fibrosis. This study was undertaken to …

The hepatic stellate (Ito) cell lies within the space of Disse and has a variety of functions.
Stellate cells store vitamin A in characteristic lipid droplets. In the normal human liver, the …

The alcohol‐inducible cytochrome P450 2E1 (CYP2E1) is expressed mainly in hepatocytes
and generates reactive oxygen species (ROS). To better understand how hepatic stellate …