Dithranol is a therapeutic agent mainly used for psoriasis; however, its clinical use is limited
by poor stability, skin irritation, and low patient compliance with conventional formulations …

Background Many candidate vaccine strategies against human immunodeficiency virus
(HIV) infection are under study, but their clinical development is lengthy and iterative. To …

Traditionally, phase II single-arm trials are based on a binary response variable that
represents the efficacy of the experimental treatment. However, the introduction of an …

In oncology, Phase II studies are crucial for clinical development plans as such studies
identify potent agents with sufficient activity to continue development in the subsequent …

Bayesian monitoring strategies based on predictive probabilities are widely used in phase II
clinical trials that involve a single efficacy binary variable. The essential idea is to control the …

Most exploratory clinical trials in cancer are designed as single‐arm trials using a binary
efficacy outcome with or without interim monitoring. In this context, we have proposed a …

The experimental design presented here is motivated by a phase II clinical trial called
PePS2, investigating the efficacy and safety of an immunotherapy called pembrolizumab in …

Efficiency is a perennial motivation of statistical analysis and clinical trials. This is most
pertinent when sample size is constrained. When trials and their analyses are more efficient …

Comments on ‘Application of an adaptive design to a randomized phase II selection trial in
gastric cancer: a report of the study design’ by Satoshi Morita and Junichi Sakamoto …

In this article we consider the sample size determination problem in the context of robust
Bayesian parameter estimation of the Bernoulli model. Following a robust approach, we …