[HTML][HTML] Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

SS Plotkin, NR Cashman - Neurobiology of Disease, 2020 - Elsevier
Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …

[HTML][HTML] Advances and considerations in AD tau-targeted immunotherapy

A Bittar, N Bhatt, R Kayed - Neurobiology of disease, 2020 - Elsevier
The multifactorial and complex nature of Alzheimer's disease (AD) has made it difficult to
identify therapeutic targets that are causally involved in the disease process. However …

Modulation of disordered proteins with a focus on neurodegenerative diseases and other pathologies

AHS Martinelli, FC Lopes, EBO John… - International journal of …, 2019 - mdpi.com
Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in
their folding depending on the environment or ligands. Intrinsically disordered proteins are …

Atrial fibrillation and cognitive impairment: new insights and future directions

AS Shamloo, N Dagres, A Muessigbrodt… - Heart, Lung and …, 2020 - Elsevier
Introduction Atrial fibrillation (AF) has been recognised as the most prevalent sustained
arrhythmia. Recently, a growing body of evidence has suggested that AF might be involved …

Have there been improvements in Alzheimer's disease drug discovery over the past 5 years?

R Cacabelos - Expert opinion on drug discovery, 2018 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is the most important neurodegenerative disorder
with a global cost worldwide of over $700 billion. Pharmacological treatment accounts for 10 …

Tau protein as therapeutic target for cancer? Focus on glioblastoma

R Hedna, H Kovacic, A Pagano, V Peyrot, M Robin… - Cancers, 2022 - mdpi.com
Simple Summary Tau protein is a microtubule-associated protein, widely known for its role in
neurodegenerative diseases. Recent studies show that Tau can also be involved in the …

Peptide-based vaccines for neurodegenerative diseases: Recent endeavors and future perspectives

V Vassilakopoulou, CE Karachaliou, A Evangelou… - Vaccines, 2021 - mdpi.com
The development of peptide-based vaccines for treating human neurodegenerative
diseases has been the eventual aim of many research endeavors, although no active …

Current status of drug targets and emerging therapeutic strategies in the management of Alzheimer's disease

S Ghosh, S Durgvanshi, S Agarwal… - Current …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease affecting the elderly. AD is
associated with a progressive decline in memory and cognitive abilities, drastic changes in …

The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy

Y Chen, X Hou, J Pang, F Yang, A Li, S Lin… - Frontiers in Molecular …, 2022 - frontiersin.org
Epilepsy is a common symptom of many neurological disorders and can lead to neuronal
damage that plays a major role in seizure-related disability. The peptidyl-prolyl isomerase …

Recent advances in tau-directed immunotherapy against Alzheimer's disease: an overview of pre-clinical and clinical development

PY Ng, IS Chang, RY Koh, SM Chye - Metabolic Brain Disease, 2020 - Springer
Alzheimer's disease (AD) has been a worldwide concern for many years now. This is due to
the fact that AD is an irreversible and progressive neurodegenerative disease that affects …