Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …

Cancer cells exhibit molecular characteristics that confer them different proliferative
capacities and survival advantages to adapt to stress conditions, such as deregulation of …

Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living
organisms, with a broad spectrum of pharmacological activities and therapeutic potential …

Animal venoms are a rich source of bioactive peptides that efficiently modulate key receptors
and ion channels involved in cellular excitability to rapidly neutralize their prey or predators …

This work shows the antitumor and antimetastatic effects of BthTX-II, an Asp-49 PLA 2 from
Bothrops jararacussu venom, on MDA-MB-231 human triple negative breast cancer cells …

Highlights•Limitations of current cancer therapy prompt exploration of novel drugs from
natural sources.•Purified Indian snake venom toxins have tremendous anticarcinogenic …

Due to the lack of chemotherapeutic drugs that selectively affect cervical cancer cells,
natural sources such as snake venom are currently being investigated for molecules with …

RNA purification and cDNA synthesis represents the starting point for molecular analyses of
snake venom proteins-enzymes. Usually, the sacrifice of snakes is necessary for venom …

Antiangiogenic strategies are promising tools for cancer treatment and several other
disorders. In this sense, phospholipases A 2 (PLA 2 s) from snake venom have been …