Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in
autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is …

FOXP3+ regulatory T cells (Tregs) are central for peripheral tolerance, and their
deregulation is associated with autoimmunity. Dysfunctional autoimmune Tregs display pro …

Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive
inflammation, and support tissue repair processes. Therefore, Treg cells are currently …

Cell therapy is a promising strategy for treating patients suffering from autoimmune or
inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have …

Acute graft-versus-host disease (GvHD) is a major cause of mortality in allogeneic bone
marrow transplantation (BMT), for which administration of FoxP3+ regulatory T (Treg) cells …

A current pressing need in cancer immunology is the development of preclinical model
systems that are immunocompetent for the study of human tumors. Here, we report the …

The occurrence of Graft-versus-Host Disease (GvHD) is a prevalent and potentially lethal
complication that develops following hematopoietic stem cell transplantation. Humanized …

T‐regulatory cells (Tregs) have a fundamental role in the establishment and maintenance of
peripheral tolerance. There is now compelling evidence that deficits in the numbers and/or …