ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer

R Sugiura, R Satoh, T Takasaki - Cells, 2021 - mdpi.com
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Kaempferol: A key emphasis to its anticancer potential

M Imran, B Salehi, J Sharifi-Rad, T Aslam Gondal… - Molecules, 2019 - mdpi.com
A marked decrease in human cancers, including breast cancer, bone cancer, and cervical
cancer, has been linked to the consumption of vegetable and fruit, and the corresponding …

Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids

M Kawser Hossain, A Abdal Dayem, J Han… - International journal of …, 2016 - mdpi.com
Obesity and diabetes are the most prevailing health concerns worldwide and their incidence
is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease …

Cancer chemoprevention: A strategic approach using phytochemicals

M Swetha, CK Keerthana, TP Rayginia… - Frontiers in …, 2022 - frontiersin.org
Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing
tumor incidence using synthetic or natural bioactive agents. Mechanistically …

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

AY Chen, YC Chen - Food chemistry, 2013 - Elsevier
Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic …

A review on the dietary flavonoid kaempferol

JM Calderon-Montano, E Burgos-Morón… - Mini reviews in …, 2011 - ingentaconnect.com
Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective
effect on human health. Identifying bioactive dietary constituents is an active area of …

Bioactive flavonoids in Moringa oleifera and their health-promoting properties

M Lin, J Zhang, X Chen - Journal of functional foods, 2018 - Elsevier
Moringa oleifera is widely cultivated as an important vegetable for human consumption.
Moringa contains numerous dietary phytonutrients, including flavonoids, which are …

Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways

A Almatroudi, KS Allemailem, WM Alwanian… - International Journal of …, 2023 - mdpi.com
Cancer is the principal cause of death and its incidence is increasing continuously
worldwide. Various treatment approaches are in practice to treat cancer, but these treatment …

Therapeutic importance of kaempferol in the treatment of cancer through the modulation of cell signalling pathways

MY Qattan, MI Khan, SH Alharbi, AK Verma… - Molecules, 2022 - mdpi.com
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been
widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show …

Evidence to support the anti-cancer effect of olive leaf extract and future directions

A Boss, KS Bishop, G Marlow, MPG Barnett… - Nutrients, 2016 - mdpi.com
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of
cardiovascular disease and cancers. The main components of this diet include high intake of …