Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

Completion of lagging strand DNA synthesis requires processing of up to 50 million Okazaki
fragments per cell cycle in mammalian cells. Even in yeast, the Okazaki fragment maturation …

During lagging strand chromatin replication, multiple Okazaki fragments (OFs) require
processing and nucleosome assembly, but the mechanisms linking these processes remain …

Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem
disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the …

Friedreich's ataxia (FRDA) is a human hereditary disease caused by the presence of
expanded (GAA) n repeats in the first intron of the FXN gene [V. Campuzano et al., Science …

There is compelling evidence that proliferating cell nuclear antigen (PCNA), a DNA sliding
clamp, co-ordinates the processing and joining of Okazaki fragments during eukaryotic DNA …

The minichromosome maintenance protein 10 (Mcm10) is an evolutionarily conserved factor
that is essential for replication initiation and elongation. Mcm10 is part of the eukaryotic …

Tandem repeat expansion is responsible for the Repeat Expansion Diseases, a group of
human genetic disorders that includes Fragile X syndrome (FXS). FXS results from …