Cells respond to diverse types of mechanical stimuli using a wide range of plasma membrane-associated mechanosensitive receptors to convert extracellular mechanical cues …
A Argyriou, MH Wadsworth, A Lendvai… - Nature …, 2022 - nature.com
Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial joints where different CD4+ T cell subsets may contribute to pathology. Here, we perform single cell sequencing …
M van der Poel, T Ulas, MR Mizee, CC Hsiao… - Nature …, 2019 - nature.com
Here we report the transcriptional profile of human microglia, isolated from normal- appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non …
NL Fransen, CC Hsiao, M van der Poel… - Brain, 2020 - academic.oup.com
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines. We …
J Yeung, R Adili, EN Stringham, R Luo… - Proceedings of the …, 2020 - National Acad Sciences
Circulating platelets roll along exposed collagen at vessel injury sites and respond with filipodia protrusion, shape change, and surface area expansion to facilitate platelet …
F Bassilana, M Nash, MG Ludwig - Nature reviews Drug discovery, 2019 - nature.com
Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR superfamily—have several atypical characteristics, including large, multi-domain N termini …
Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus …
KL Truong, S Schlickeiser, K Vogt, D Boës… - Nature …, 2019 - nature.com
All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined …
AK Singh, HH Lin - Biomedical journal, 2021 - Elsevier
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system …