Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

Ligands and beyond: Mechanosensitive adhesion GPCRs

HH Lin, KF Ng, TC Chen, WY Tseng - Pharmaceuticals, 2022 - mdpi.com
Cells respond to diverse types of mechanical stimuli using a wide range of plasma
membrane-associated mechanosensitive receptors to convert extracellular mechanical cues …

Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis

A Argyriou, MH Wadsworth, A Lendvai… - Nature …, 2022 - nature.com
Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial joints where different
CD4+ T cell subsets may contribute to pathology. Here, we perform single cell sequencing …

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

M van der Poel, T Ulas, MR Mizee, CC Hsiao… - Nature …, 2019 - nature.com
Here we report the transcriptional profile of human microglia, isolated from normal-
appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non …

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

NL Fransen, CC Hsiao, M van der Poel… - Brain, 2020 - academic.oup.com
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

J Yeung, R Adili, EN Stringham, R Luo… - Proceedings of the …, 2020 - National Acad Sciences
Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …

Adhesion G protein-coupled receptors: opportunities for drug discovery

F Bassilana, M Nash, MG Ludwig - Nature reviews Drug discovery, 2019 - nature.com
Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

A guide to adhesion GPCR research

I Liebscher, O Cevheroğlu, CC Hsiao… - The FEBS …, 2022 - Wiley Online Library
Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus …

Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells

KL Truong, S Schlickeiser, K Vogt, D Boës… - Nature …, 2019 - nature.com
All memory T cells mount an accelerated response on antigen reencounter, but significant
functional heterogeneity is present within the respective memory T-cell subsets as defined …

[HTML][HTML] The role of GPR56/ADGRG1 in health and disease

AK Singh, HH Lin - Biomedical journal, 2021 - Elsevier
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the
physiological functions of the central and peripheral nervous systems, reproductive system …