Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …

The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Keratins form the major intermediate filament cytoskeleton of epithelia and are assembled
from heterodimers of 28 type I and 26 type II keratins in cell-and differentiation-dependent …

The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important
roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed …

Keratins are cytoskeletal filament-forming proteins found in skin and other epithelial (sheet)
tissues (Table 1). Keratins (type I and II), and other highly related (types III–VI) intermediate …

The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …

The mechanical properties of vertebrate cells are largely defined by the system of
intermediate filaments (IF). As part of a dense network, IF polymers are constantly …