Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases

E Cano-Gamez, G Trynka - Frontiers in genetics, 2020 - frontiersin.org
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk

AW Turner, SS Hu, JV Mosquera, WF Ma… - Nature …, 2022 - nature.com
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …

Heart disease and stroke statistics—2020 update: a report from the American Heart Association

SS Virani, A Alonso, EJ Benjamin, MS Bittencourt… - Circulation, 2020 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …

Heart disease and stroke statistics—2021 update: a report from the American Heart Association

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - Circulation, 2021 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Stroke genetics: discovery, biology, and clinical applications

M Dichgans, SL Pulit, J Rosand - The Lancet Neurology, 2019 - thelancet.com
Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …

[HTML][HTML] Editor's Choice–Prevalence of Peripheral Arterial Disease, Abdominal Aortic Aneurysm, and Risk Factors in the Hamburg City Health Study: A Cross Sectional …

CA Behrendt, G Thomalla, DL Rimmele… - European Journal of …, 2023 - Elsevier
Objective There is a paucity of current figures on the prevalence of carotid and lower
extremity peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA) as well as …

Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian randomization study

MK Georgakis, R Malik, D Gill… - Circulation: Genomic …, 2020 - Am Heart Assoc
Downregulation of IL-6 (interleukin-6) signaling has been proposed as a strategy for
lowering cardiovascular risk. Secondary analyses from CANTOS (Canakinumab Anti …

Cohort profile: the LIFE-adult-study

C Engel, K Wirkner, S Zeynalova… - International Journal …, 2023 - academic.oup.com
International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …