Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Developmental alterations of excitatory synapses are implicated in autism spectrum
disorders (ASDs). Here, we report increased dendritic spine density with reduced …

Macroautophagy/autophagy is vital for neuronal homeostasis and functions. Accumulating
evidence suggest that autophagy is impaired during cerebral ischemia, contributing to …

Circular RNAs (circRNAs) are a naturally occurring family of noncoding RNAs (ncRNAs)
highly represented in the eukaryotic transcriptome. Recently characterized, traditional …

Objective: Diverse autolysosomal proteins were quantified in neurally derived blood
exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered …

Circular RNAs (circRNAs) represent a special group of noncoding single-stranded highly
stable ribonucleic acid entities abundant in the eukaryotic transcriptome. These circular …

Post-translational modification of proteins by ubiquitin is a fundamentally important
regulatory mechanism. However, proteome-wide analysis of endogenous ubiquitylation …

Neuronal activity induces the post-translational modification of synaptic molecules, promotes
localized protein synthesis within dendrites and activates gene transcription, thereby …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …