Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Although inflammatory and immunological reactions protect the host from invasion by
microorganisms and eliminate debris at sites of tissue injury, they can also be responsible …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Angiogenesis is the growth of blood vessels from the existing vasculature. The field of
angiogenesis has grown enormously in the past 30 years, with only 40 papers published in …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

During tumor growth, angiogenesis is required to ensure oxygen and nutrient transport to
the tumor. Vascular endothelial growth factor (VEGF) is the major inducer of angiogenesis …

There is increasing evidence that platelets play an important role in the process of tumor
angiogenesis. Thrombocytosis is a frequent finding in cancer patients (10–57%). Although …