Aims To investigate how variability in activation sequence and passive conduction
properties translates into clinical variability in QRS biomarkers, and gain novel physiological …

To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is
required. We introduce a novel screening system for drug-induced arrhythmogenic risk that …

The ear is well positioned to accommodate both brain and vital signs monitoring, via so-
called hearable devices. Consequently, ear-based electroencephalography has recently …

Mobile technologies for the recording of vital signs and neural signals are envisaged to
underpin the operation of future health services. For practical purposes, unobtrusive devices …

A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce
all the fundamental activities of the working heart, including propagation of excitation …

Background The currently proposed criteria for identifying patients who would benefit from
cardiac resynchronization therapy (CRT) still need to be optimized. A multi-scale heart …

For treatment of complex congenital heart disease, computer simulation using a three-
dimensional heart model may help to improve outcomes by enabling detailed preoperative …

Aims A pre-operative non-invasive identification of the site of origin (SOO) of outflow tract
ventricular arrhythmias (OTVAs) is important to properly plan radiofrequency ablation …

When generating in-silico clinical electrophysiological outputs, such as electrocardiograms
(ECGs) and body surface potential maps (BSPMs), mathematical models have relied on …

ST elevation on an electrocardiogram is a hallmark of acute transmural ischemia. However,
the underlying mechanism remains unclear. We hypothesized that high ischemic …