Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract

AC Fenneman, M Weidner, LA Chen… - Nature Reviews …, 2023 - nature.com
Antibiotic use is increasing worldwide. However, the use of antibiotics is clearly associated
with changes in gut microbiome composition and function, and perturbations have been …

The role of short-chain fatty acids and bile acids in intestinal and liver function, inflammation, and carcinogenesis

A Visekruna, M Luu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
During the past decade, researchers have investigated the role of microbiota in health and
disease. Recent findings support the hypothesis that commensal bacteria and in particular …

Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for …

KE Masse, VB Lu - Frontiers in Endocrinology, 2023 - frontiersin.org
The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The
metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that …

Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance

B Peng, H Li, X Peng - Drug Discovery Today, 2023 - Elsevier
Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …

Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis

X Guo, C Li, J Zhang, M Sun, J Xu, C Xu, H Kuang… - Nature Aging, 2023 - nature.com
Alzheimer's disease (AD) is characterized by amyloid-β accumulation in the brain and
hyperphosphorylated tau aggregation, as well as neuroinflammation. The gut–brain axis has …

A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation

C Zhang, L Yu, C Ma, S Jiang, Y Zhang, S Wang… - Cell Host & Microbe, 2023 - cell.com
Impaired gastrointestinal motility is associated with gut dysbiosis. Probiotics, such as
Bifidobacteria, can improve this bowel disorder; however, efficacy is strain-dependent. We …

Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota

Z Yu, IR Henderson, J Guo - Gut Microbes, 2023 - Taylor & Francis
Non-caloric artificial sweeteners have been widely permitted as table sugar substitutes with
high intensities of sweetness. They can pass through the intestinal tract without significant …

Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment

W Wei, Y Liu, Y Hou, S Cao, Z Chen, Y Zhang, X Cai… - Cell Metabolism, 2024 - cell.com
The brain and gut are intricately connected and respond to various stimuli. Stress-induced
brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The …

The antimicrobial peptide LI14 combats multidrug-resistant bacterial infections

J Shi, C Chen, D Wang, Z Wang, Y Liu - Communications Biology, 2022 - nature.com
The prevalence of multidrug-resistant (MDR) pathogens raises public fears of untreatable
infections and represents a huge health risk. There is an urgent need to exploit novel …