Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Animal studies have been instrumental in providing evidence for exercise-induced
neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson's disease …

Epidemiological studies indicate that physical activity and exercise may reduce the risk of
developing Parkinson's disease (PD), and clinical observations suggest that physical …

Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of
pharmacological modulations on brain function in a non-invasive and longitudinal manner …

Objective: To compare the effects of 2 forms of exercise, ie, a 6-week trial of treadmill training
with virtual reality (TT+ VR) that targets motor and cognitive aspects of safe ambulation and …

Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with
emergence of adult executive function and top‐down inhibitory control over behavior …

Background Aerobic exercise training (AET) has been shown to provide general health
benefits, and to improve motor behaviours in particular, in individuals with Parkinson's …

Rodent models have opened the door to a better understanding of the neurobiology of brain
disorders and increased our ability to evaluate novel treatments. Resting-state functional …

Background Falls are frequent in Parkinson's disease and aging. Impairments in the
cholinergic-mediated attentional supervision of gait may contribute to increased fall risk …

There is a proliferation of research examining the effects of exercise on mobility and
cognition in the general population and those with neurological disorders as well as focal …