[PDF][PDF] Recent developments in the CCP-EM software suite
As part of its remit to provide computational support to the cryo-EM community, the
Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced …
Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced …
Impact of cytosine methylation on DNA binding specificities of human transcription factors
INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …
Molecular replacement with MOLREP
A Vagin, A Teplyakov - Acta Crystallographica Section D: Biological …, 2010 - journals.iucr.org
MOLREP is an automated program for molecular replacement that utilizes a number of
original approaches to rotational and translational search and data preparation. Since the …
original approaches to rotational and translational search and data preparation. Since the …
Structural basis for SARM1 inhibition and activation under energetic stress
M Sporny, J Guez-Haddad, T Khazma, A Yaron… - Elife, 2020 - elifesciences.org
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
A molecular mechanism for direct sirtuin activation by resveratrol
M Gertz, GTT Nguyen, F Fischer, B Suenkel… - PloS one, 2012 - journals.plos.org
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging
processes, and they were suggested to mediate the lifespan extending effect of a low calorie …
processes, and they were suggested to mediate the lifespan extending effect of a low calorie …
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
M Gertz, F Fischer, GTT Nguyen… - Proceedings of the …, 2013 - National Acad Sciences
Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven
human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are …
human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
Structural basis of androgen receptor binding to selective androgen response elements
PL Shaffer, A Jivan, DE Dollins… - Proceedings of the …, 2004 - National Acad Sciences
Steroid receptors bind as dimers to a degenerate set of response elements containing
inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally …
inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally …
[HTML][HTML] A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
The AP2 adaptor complex (α, β2, σ2, and μ2 subunits) crosslinks the endocytic clathrin
scaffold to PtdIns4, 5P 2-containing membranes and transmembrane protein cargo. In the" …
scaffold to PtdIns4, 5P 2-containing membranes and transmembrane protein cargo. In the" …
CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state
Translational control is an essential process for the cell to adapt to varying physiological or
environmental conditions. To survive adverse conditions such as low nutrient levels …
environmental conditions. To survive adverse conditions such as low nutrient levels …