CEM43 has its roots in the direct cytotoxic effect of heat, whereby the amount of cell death
depends on the temperature and exposure time. CEM43 is a normalising method to convert …

Clinically achievable mild temperature local hyperthermia (< 43° C) has been demonstrated
to be an effective adjuvant to radiotherapy in pre-clinical and clinical studies. In this article …

Copper (II)-diacetyl-bis (N4-methylthiosemicarbazone), Cu–ATSM, labeled with a positron
emitting isotope of copper (60Cu, 61Cu, 62Cu or 64Cu) has been shown, in vitro and in vivo …

Biological modeling for anti-cancer treatments using mathematical models can be very
supportive in gaining more insight into dynamic processes responsible for cellular response …

External beam radiation therapy procedures have, until recently, been planned almost
exclusively using anatomic imaging methods. Molecular imaging using hybrid positron …

OBJECTIVE. Copper-diacetyl-bis (N4-methylthiosemicarbazone)(Cu-ATSM) and copper-
pyruvaldehyde-bis (N4-methylthiosemicarbazone)(Cu-PTSM) are being studied as potential …

Purpose: In vitro data demonstrate that heat-induced radiosensitisation is maximised if
hyperthermia and radiotherapy are given simultaneously, with the radiation fraction …

In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor
prognosis and resistance to both radiation therapy and chemotherapy. As the development …

Role of positron emission tomography in the management of he... : Current Opinion in Oncology
Role of positron emission tomography in the management of head and neck cancer in the …

The contribution of positron emission tomography (PET) to the drug discovery and
development (D3) pipeline has been inhibited by the short half-lifes of PET radioisotopes …