Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

The development of iPSCs reflected the merging of three major scientific streams and has in
turn led to additional new branches of investigation. However, there is still debate about …

The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use
patient-specific somatic cells, which are a valuable source for disease modeling and drug …

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through …

The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by
reprogramming is accompanied by a global remodeling of the epigenome,,,,, resulting in …

Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …