Lamin B Receptor (LBR) is an integral membrane protein of the interphase nuclear
envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Summary In medium-resolution (7–10 Å) cryo-electron microscopy (cryo-EM) density maps,
α helices can be identified as density rods whereas β-strand or loop regions are not as …

Cryo-electron microscopy (cryo-EM) enables the imaging of macromolecular complexes in
near-native environments at resolutions that often permit the visualization of secondary …

Recent advances in cryo-electron microscopy have led to an increasing number of high (3–
5Å) to medium (5–10Å) resolution cryoEM density maps. These density maps contain …

Hybrid approaches combine computational methods with experimental data. The
information contained in the experimental data can be leveraged to probe the structure of …

We identify a structural feature of transmembrane helical proteins that restricts their
conformational space and suggests a new way of understanding the construction and …

Cryo‐electron microscopy is a powerful technique for the determination of three‐
dimensional (3D) structures of macromolecular machines, as it provides functional …

We present an approach for incorporating solvent accessibility data from electron
paramagnetic resonance experiments in the structural refinement of membrane proteins …

This review surveys recent achievements of molecular computer modeling in understanding
spatial structure, dynamics, and mechanisms of functioning of transmembrane α-helical …