Interstitial cells: regulators of smooth muscle function

KM Sanders, SM Ward, SD Koh - Physiological reviews, 2014 - journals.physiology.org
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

The enteric nervous system and regulation of intestinal motility

WAA Kunze, JB Furness - Annual review of physiology, 1999 - annualreviews.org
▪ Abstract The enteric nervous system exerts local control over mixing and propulsive
movements in the small intestine. When digestion is in progress, intrinsic primary afferent …

[图书][B] The enteric nervous system

JB Furness - 2008 - books.google.com
Covers all aspects of the structure, function, neurochemistry, transmitter identification and
development of the enteric nervous system This book brings together extensive knowledge …

Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach.

AJ Burns, AE Lomax, S Torihashi… - Proceedings of the …, 1996 - National Acad Sciences
The structural relationships between interstitial cells of Cajal (ICC), varicose nerve fibers,
and smooth muscle cells in the gastrointestinal tract have led to the suggestion that ICC may …

The enteric nervous system and its emerging role as a therapeutic target

MA Fleming, L Ehsan, SR Moore… - … research and practice, 2020 - Wiley Online Library
The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS), an
extensive neuronal network that traverses along its walls. Due to local reflex circuits, the …

Nitric oxide and its role as a non‐adrenergic, non‐cholinergic inhibitory neurotransmitter in the gastrointestinal tract

KM Sanders, SM Ward - British Journal of Pharmacology, 2019 - Wiley Online Library
NO is a neurotransmitter released from enteric inhibitory neurons and responsible for
modulating gastrointestinal (GI) motor behaviour. Enteric neurons express nNOS (NOS1) …

c-kit-Dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract

S Torihashi, SM Ward, SI Nishikawa, K Nishi… - Cell and tissue …, 1995 - Springer
In vivo injection of a neutralizing, monoclonal antibody (ACK2) to the receptor tyrosine
kinase (c-kit) disrupts the normal motility patterns of the mouse small intestine …

Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP …

PJ Smet, J Jonavicius, VR Marshall, J De Vente - Neuroscience, 1996 - Elsevier
The distribution of nerves with the potential to synthesize nitric oxide was examined within
the urinary bladder and proximal urethra of humans and guinea-pigs, using an antibody to …

[HTML][HTML] The significance of interstitial cells in neurogastroenterology

PJ Blair, PL Rhee, KM Sanders… - Journal of …, 2014 - ncbi.nlm.nih.gov
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of
cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin …

Interstitial cells of Cajal: primary targets of enteric motor innervation

SM Ward, KM Sanders - … Record: An Official Publication of the …, 2001 - Wiley Online Library
For many years morphologists have noted the close relationship between interstitial cells of
Cajal (ICC) and nerve fibers within the tunica muscularis of gastrointestinal (GI) organs …