Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Simple Summary Intratumoral heterogeneity is considered the major cause of drug
resistance and hence treatment failure in cancer patients. Tumor cells are known for their …

Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Background: While soft-tissue sarcomas (STSs) are rare tumors, liposarcomas are among
the most common type of STS and are divided into four main subtypes: atypical lipomatous …

Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …

Abstract Pioglitazone is a Peroxisome Proliferator-Activated Receptor (PPAR) agonist of the
thiazolidinedione class of compounds with promising anticancer activity. An innovative …

After Evans and colleagues identified the lipomatous tumor with a well-differentiated
liposarcoma in a subcutaneous location or within a muscle layer, namely, atypical …

Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into
several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte …

Aims Accumulating evidence has confirmed the involvement of the homeobox (HOX) gene
family in carcinogenesis. HOXC11, belongs to the homeobox-C (HOXC) gene cluster, has …

The in-silico strategy of identifying novel uses for already existing drugs, known as drug
repositioning, has enhanced drug discovery. Previous studies have shown a positive …