Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we
report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a
colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting …

Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of
unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps …

FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA
interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet,
replication-mediated genomic instability is integral to oncogenesis, and p53 mutations …

Replication fork reversal is an important mechanism to protect the stability of stalled forks
and thereby preserve genomic integrity. While multiple enzymes have been identified that …