The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …

Aptamers have been identified against various targets as a type of chemical or nucleic acid
ligand by systematic evolution of ligands by exponential enrichment (SELEX) with high …

Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to
bind a wide range of biomedically relevant proteins with affinities and specificities that are …

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major
constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by …

Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …

Aptamers and SELEX (systematic evolution of ligands by exponential enrichment)
technology have gained increasing attention over the past 25 years. Despite their functional …

Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …