Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Heart failure with reduced ejection fraction (HFrEF) develops when cardiac output falls as a
result of cardiac injury. The most well-recognized of the compensatory homeostatic …

Rationale: The initial hypertrophy response to cardiac pressure overload is considered
compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role …

Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

The cardiovascular safety of nicotine is an important question in the current debate on the
benefits vs. risks of electronic cigarettes and related public health policy. Nicotine exerts …

Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …

Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant
states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even …

After ischemic stroke, there is a significant burden of cardiovascular complications, both in
the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of …

Background: Genome-wide transcriptome analysis has greatly advanced our understanding
of the regulatory networks underlying basic cardiac biology and mechanisms driving …