Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-
associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

During tumor development, invasion and metastasis, the intimate interaction between tumor
and stroma shapes the tumor microenvironment and dictates the fate of tumor cells. Stromal …

Background Clinical drawback in checkpoint inhibitors immunotherapy (ICI) of metastatic
melanoma (MM) is monitoring clinical benefit. Soluble forms of PD1 (sPD1) and PD-L1 (sPD …

Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment
(TME) and an important contributor to cancer progression and therapeutic resistance …

Chimeric antigen receptor (CAR) T cells (CAR-T) have dramatically changed the treatment
landscape of B-cell malignancies, providing a potential cure for relapsed/refractory patients …

Purpose To explore the predictive merit of MFAP2+ cancer associated fibroblasts (CAFs)
infiltration for clinical outcomes and adjuvant chemotherapy or immunotherapy …

We analyzed the incidence of bone marrow fibrosis in 91 newly diagnosed Japanese
multiple myeloma (MM) patients and evaluated the impact of fibrosis on clinical …

Cancer-associated fibroblasts (CAFs) in the cancer microenvironment play an essential role
in metastasis. Differentiation of endothelial cells into CAFs is induced by cancer cell-derived …

Abstract Background BRAF inhibitor (BRAF-I) therapy for melanoma patients harboring the
V600E mutation is initially highly effective, but almost all patients relapse within a few …