Recent advances in understanding the role of mitochondrial dysfunction in
neurodegenerative diseases have expanded the opportunities for neurotherapeutics …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …

In brief Oxidative stress is recognized as an underlying driving factor of both telomere
dysfunction and human subfertility/infertility. This review briefly reassesses telomere integrity …

The telomeric noncoding RNA TERRA is a key component of telomeres and it is widely
expressed in normal as well as cancer cells. In the last 15 years, several publications have …

Plant-derived exosomes (PDEs) are receiving much attention as a natural source of
antioxidants. Previous research has shown that PDEs contain a series of bioactives and that …

Background Age-related changes in the ovarian microenvironment are linked to impaired
fertility in women. Macrophages play important roles in ovarian tissue homeostasis and …

While at the organismal level, biological aging can be estimated by telomere length and
DNA methylation signatures, reliable biomarkers that can predict reproductive age are much …

Ferroptosis is a novel form of regulated cell death trigged by various biological processes,
and p53 is involved in different ferroptosis regulations and functions as a crucial regulator …

Aim In developed nations, women have increasingly deferred childbearing, leading to a rise
in demand for infertility treatments and the widespread use of assisted reproductive …