Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
Therapies with genetically modified T cells that express chimeric antigen receptors (CARs)
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …
A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
EGFR in cancer: Signaling mechanisms, drugs, and acquired resistance
ML Uribe, I Marrocco, Y Yarden - Cancers, 2021 - mdpi.com
Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
First-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provide significant clinical
benefit in patients with advanced EGFR-mutant (EGFRm+) non–small cell lung cancer …
benefit in patients with advanced EGFR-mutant (EGFRm+) non–small cell lung cancer …
Current and future strategies for treatment of glioma
NAO Bush, SM Chang, MS Berger - Neurosurgical review, 2017 - Springer
Gliomas are one of the most common types of primary brain tumors and have remained
particularly challenging to treat. This review illustrates a multidisciplinary approach to the …
particularly challenging to treat. This review illustrates a multidisciplinary approach to the …
Glioblastoma: pathology, molecular mechanisms and markers
K Aldape, G Zadeh, S Mansouri, G Reifenberger… - Acta …, 2015 - Springer
Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
Pathological and molecular features of glioblastoma and its peritumoral tissue
A D'Alessio, G Proietti, G Sica, BM Scicchitano - Cancers, 2019 - mdpi.com
Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …
present, GBMs are divided in primary and secondary on the basis of the mutational status of …
The ErbB/HER family of protein-tyrosine kinases and cancer
R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2
Abstract Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their
mechanisms of action are mainly undocumented. Through public glioma mRNA expression …
mechanisms of action are mainly undocumented. Through public glioma mRNA expression …
Exploiting the curative potential of adoptive T‐cell therapy for cancer
CS Hinrichs, SA Rosenberg - Immunological reviews, 2014 - Wiley Online Library
Adoptive T‐cell therapy (ACT) is a potent and flexible cancer treatment modality that can
induce complete, durable regression of certain human malignancies. Long‐term follow‐up …
induce complete, durable regression of certain human malignancies. Long‐term follow‐up …