Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic potential if targeted …
AJ Czaja - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti- inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …
ME Guicciardi, H Malhi, JL Mott… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Because of its unique function and anatomical location, the liver is exposed to a multitude of toxins and xenobiotics, including medications and alcohol, as well as to infection by …
KQ De Andrade, FA Moura, JM Dos Santos… - International journal of …, 2015 - mdpi.com
Liver disease is highly prevalent in the world. Oxidative stress (OS) and inflammation are the most important pathogenetic events in liver diseases, regardless the different etiology and …
Z Abassi, Z Armaly, SN Heyman - The American journal of pathology, 2020 - Elsevier
The glycocalyx is a layer coating the luminal surface of vascular endothelial cells. It is vital for endothelial function as it participates in microvascular reactivity, endothelium interaction …
X Wang, J Lei, Z Li, L Yan - Frontiers in Medicine, 2021 - frontiersin.org
The coronaviruses that cause notable diseases, namely, severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and coronavirus disease 2019 (COVID …
F Yuan, B Wang, JT Hou, J Li, J Shen, Y Duan… - Sensors and Actuators B …, 2023 - Elsevier
The spatiotemporal inspection of ROS behavior during liver fibrosis (LF) progression can facilitate its diagnosis and anti-oxidant therapy. However, none of fluorescent probes for …
P Lam, F Cheung, HY Tan, N Wang, MF Yuen… - International Journal of …, 2016 - mdpi.com
The liver is intimately connected to inflammation, which is the innate defense system of the body for removing harmful stimuli and participates in the hepatic wound-healing response …
Hydrogen sulfide (H 2 S) is a gasotransmitter that regulates numerous physiological and pathophysiological processes in our body. Enzymatic production of H 2 S is catalyzed by …