TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

One of the most crucial branches of regenerative medicine is cell therapy, in which cellular
material is injected into the patient to initiate the regenerative process. Cells obtained by …

Human pluripotent stem cells represent a powerful tool to study human embryonic
development and disease but also open up novel strategies for cell replacement therapies …

Various somatic cell types are suitable for induced pluripotency reprogramming, such as
dermal fibroblasts, mesenchymal stem cells or hair keratinocytes. Harvesting primary …

Ferrets are an attractive mammalian model for several diseases, especially those affecting
the lungs, liver, brain, and kidneys. Many chronic human diseases have been difficult to …

Background The reactivation of genetic programs from early development is a common
mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box …

Keratinocytes, as a primary somatic cell source, offer exceptional advantages compared to
fibroblasts, which are commonly used for reprogramming. Keratinocytes can beat fibroblasts …

Suspension spheroid cultures of anchorage‐dependent cell types have been widely used in
cancer and stem cell research, as well as for producing organoids. It is believed that the 3 …

Abstract Elevation of [Na+] i/[K+] i-ratio is considered as one of the major signals triggering
transcriptomic changes in various cells types. In this study, we identified ubiquitous and cell …

Induced pluripotent stem cells (iPSCs) derived using integration-free reprogramming
approaches have improved the prospects of these cells for various biomedical applications …