Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein
(ADNP), have recently been found to underlie Helsmoortel–Van der Aa syndrome, a …

Highlights•The activity of writers and erasers of chromatin marks is coupled to the function of
reader modules.•Reader domains regulate recruitment, substrate specificity and catalysis of …

The epigenome, including DNA methylation, is stably propagated during mitotic division.
However, single-cell clonal expansion produces heterogeneous methylomes, thus raising …

The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

Stable propagation of epigenetic information is important for maintaining cell identity in
multicellular organisms. However, it remains largely unknown how mono-ubiquitinated …