Background: Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent
claudication. However, numerous research groups report that PTX also may potentially be …

Angiogenesis is the physiological process of developing new blood vessels to facilitate the
delivery of oxygen and nutrients to meet the functional demands of growing tissues. It also …

Alterations in histone modification have been linked to cancer development and
progression. Celastrol, a Chinese herbal compound, shows potent anti-tumor effects through …

Drug repositioning offers new clinical indications for old drugs. Recently, many
computational approaches have been developed to repurpose marketed drugs in human …

Immunotherapy utilizing tumor-infiltrating lymphocytes (TILs) is a promising approach for
cancer treatment. Pentoxifylline (PTXF), a xanthine derivative, exhibits antitumor properties …

Triple-negative breast cancer (TNBC) is the most aggressive type of BC with the highest
percentage of tumor-infiltrating lymphocytes (TILs). Hence, TIL therapy is considered a …

Malignant tumors require a blood supply in order to survive and spread. These tumors
obtain their needed blood from the patient's blood stream by hijacking the process of …

Cisplatin resistance frequently occurs in esophageal squamous cell carcinoma (ESCC). The
underlying mechanism for cisplatin resistance in ESCC remains largely obscure. Here we …

Background YM‐155 has been proven to be an efficient antitumor suppressor in non‐small
cell lung cancer (NSCLC) cells. However, the suppressive effect of YM‐155 on the …

Despite the success for the treatment of melanoma such as targeted molecular therapy, the
use of such treatments are expensive For this reason, this study was carried out to explore …