Approaches to advance drug discovery for neglected tropical diseases

LLG Ferreira, J de Moraes, AD Andricopulo - Drug Discovery Today, 2022 - Elsevier
Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …

Perspective on schistosomiasis drug discovery: highlights from a schistosomiasis drug discovery workshop at Wellcome Collection, London, September 2022

N Caldwell, R Afshar, B Baragaña… - ACS infectious …, 2023 - ACS Publications
In September 2022, the Drug Discovery Unit at the University of Dundee, UK, organised an
international meeting at the Wellcome Collection in London to explore the current clinical …

Drug repurposing and de novo drug discovery of protein kinase inhibitors as new drugs against schistosomiasis

B Pereira Moreira, MHW Weber, S Haeberlein… - Molecules, 2022 - mdpi.com
Schistosomiasis is a neglected tropical disease affecting more than 200 million people
worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but …

Using ChEMBL to complement schistosome drug discovery

G Padalino, A Coghlan, G Pagliuca, JE Forde-Thomas… - Pharmaceutics, 2023 - mdpi.com
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …

Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development

M Schiedel, DJB McArdle, G Padalino… - Journal of Medicinal …, 2023 - ACS Publications
Schistosomiasis is a disease affecting> 200 million people worldwide, but its treatment relies
on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we …

In vitro activity, ultrastructural analysis and in silico pharmacokinetic properties (ADMET) of thiazole compounds against adult worms of Schistosoma mansoni

DVSP da Silva, PH do Bomfim Nascimento… - Acta Tropica, 2023 - Elsevier
The present work aimed to carry out in vitro biological assays of thiazole compounds against
adult worms of Schistosoma mansoni, as well as the in silico determination of …

Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus, Enterococcus faecalis, and Their …

G Padalino, K Duggan, LAJ Mur, JY Maillard… - …, 2024 - Wiley Online Library
Antimicrobial resistance remains a global issue, hindering the control of bacterial infections.
This study examined the antimicrobial properties of 2, 3‐N, N‐diphenyl quinoxaline …

[HTML][HTML] Recent advances in anti-schistosomiasis drug discovery

EJ Marker, SL Debbert - … Helminths and Zoonoses-From Basic to …, 2022 - intechopen.com
Schistosomiasis, a parasitic disease caused by infection by helminths of the Schistosoma
genus, affects over 200 million people, primarily in the developing world. Treatment of this …

[HTML][HTML] Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

M Rawat, G Padalino, T Yeo, A Brancale, DA Fidock… - Biorxiv, 2024 - ncbi.nlm.nih.gov
The human pathogens Plasmodium and Schistosoma are each responsible for over 200
million infections annually, being particularly problematic in low-and middle-income …

PfATP2 is an essential flippase on the Plasmodium falciparum surface that influences parasite sensitivity to antiplasmodial compounds

D Qiu, E England, AM Lehane - bioRxiv, 2024 - biorxiv.org
Antimalarials play a crucial role in the fight against malaria. However, resistance of the most
virulent malaria parasite, Plasmodium falciparum, to front-line antimalarials is spreading. To …