Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Pore-forming toxins (PFTs) are released by one cell to directly inflict damage on another cell.
Hosts use PFTs, including members of the membrane attack complex/perforin protein family …

Malaria parasite release (egress) from host red blood cells involves parasite-mediated
membrane poration and rupture, thought to involve membrane-lytic effector molecules such …

Malaria continues to cause untold hardship to inhabitants of malaria-endemic regions,
causing significant morbidity and mortality that severely impact global health and the …

Because Plasmodium falciparum replicates inside of a parasitophorous vacuole (PV) within
a human erythrocyte, parasite egress requires the rupture of two limiting membranes …

Toxoplasma motility is both activated and suppressed by 3′, 5′-cyclic nucleotide
signaling. Cyclic GMP (cGMP) signaling through Toxoplasma gondii protein kinase G …

Malaria and other apicomplexan-caused diseases affect millions of humans, agricultural
animals, and pets. Cell traversal is a common feature used by multiple apicomplexan …

Apicomplexan parasites mobilize ionic calcium (Ca2+) from intracellular stores to promote
microneme secretion and facilitate motile processes including gliding motility, invasion, and …

Bovine babesiosis is a tick-borne disease caused by apicomplexan parasites of the Babesia
genus that represents a major constraint to livestock production worldwide. Currently …

This Special Issue of Toxins, entitled “Cellular Entry of Binary and Pore-Forming Bacterial
Toxins,” gives a sense of the recent advances in characterizing the functional and structural …