Glycan–lectin interactions in cancer and viral infections and how to disrupt them

SM Kremsreiter, ASH Kroell, K Weinberger… - International Journal of …, 2021 - mdpi.com
Glycan–lectin interactions play an essential role in different cellular processes. One of their
main functions is involvement in the immune response to pathogens or inflammation …

The Immune Interaction between HIV-1 Infection and Mycobacterium tuberculosis

E Du Bruyn, RJ Wilkinson - Microbiology Spectrum, 2016 - Am Soc Microbiol
The modulation of tuberculosis (TB)-induced immunopathology caused by human
immunodeficiency virus (HIV)-1 coinfection remains incompletely understood but underlies …

Proteomic profiling identifies novel proteins for genetic risk of severe COVID-19: the Atherosclerosis Risk in Communities Study

BT Steffen, JS Pankow, PL Lutsey… - Human molecular …, 2022 - academic.oup.com
Background Genome-wide association studies have identified six genetic variants
associated with severe COVID-19, yet the mechanisms through which they may affect …

Cell membrane derived platform to study virus binding kinetics and diffusion with single particle sensitivity

N Peerboom, E Schmidt, E Trybala, S Block… - ACS Infectious …, 2018 - ACS Publications
Discovery and development of new antiviral therapies essentially rely on two key factors: an
in-depth understanding of the mechanisms involved in viral infection and the development of …

From classical to unconventional: the immune receptors facilitating platelet responses to infection and inflammation

I Gautam, Z Storad, L Filipiak, C Huss, CK Meikle… - Biology, 2020 - mdpi.com
Simple Summary Platelets are small and numerous cells, second only to red blood cells in
the bloodstream. They have been recognized mainly for their contributions to blood clotting …

Risk factors associated with the clinical outcomes of COVID-19 and its variants in the context of cytokine storm and therapeutics/vaccine development challenges

J Hanna, P Tipparaju, T Mulherkar, E Lin, V Mischley… - Vaccines, 2021 - mdpi.com
The recent appearance of SARS-CoV-2 is responsible for the ongoing coronavirus disease
2019 (COVID-19) pandemic and has brought to light the importance of understanding this …

Dextran loading protects macrophages from lipid peroxidation and induces a Keap1/Nrf2/ARE-dependent antioxidant response

A Chechushkov, N Zaitseva, E Vorontsova, P Kozhin… - Life Sciences, 2016 - Elsevier
Aims Linear dextrans are often proposed as drug delivery systems with milder adverse
effects and lower effective drug concentrations. Linear dextrans are polysaccharides that …

UM15 reinforces a lymphocyte-mimicking nanotrap for precise HIV-1 inhibition

J Zhang, Z Li, J Li, H Li, J Che, T Zhao, P Zou, J Han… - Nano Research, 2023 - Springer
Even the potential of T cell-mimicking nanotrap for long term viral control due to its
overcoming of human immunodeficiency virus (HIV) genetic diversity and viral resistance …

Polyvalent glycan-quantum dots as multifunctional structural probes for multivalent lectin-carbohydrate interactions

J Hooper, Y Guo, D Zhou - Glycan-Based Cellular Communication …, 2020 - ACS Publications
Carbohydrate-binding proteins, also known as lectins, play a key role in pathogen infection,
cell-cell communication, and immune regulation. They recognize pathogen surface–specific …

Prevalence and factors associated with high concentration of prostate-specific antigen: ELSIA study

LL Galvão, S Tribess, TG Silva, CG Santa Rosa… - Biology, 2020 - mdpi.com
Simple Summary Screening for prostate cancer is critical to increasing men's longevity, and
prostate-specific antigen is the primary method of screening for this cancer. Assessing the …