[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

R Zang, MFG Castro, BT McCune, Q Zeng… - Science …, 2020 - science.org
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed
in COVID-19. However, it is unclear whether SARS-CoV-2 replicates in the human intestine …

Unraveling the mystery surrounding post-acute sequelae of COVID-19

RK Ramakrishnan, T Kashour, Q Hamid… - Frontiers in …, 2021 - frontiersin.org
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still
looming large with a paucity of treatment options. To add to this burden, a sizeable subset of …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

C Blume, CL Jackson, CM Spalluto, J Legebeke… - Nature …, 2021 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion …

Is SARS-CoV-2 also an enteric pathogen with potential fecal–oral transmission? A COVID-19 virological and clinical review

S Ding, TJ Liang - Gastroenterology, 2020 - Elsevier
In as few as 3 months, coronavirus disease 2019 (COVID-19) has spread and ravaged the
world at an unprecedented speed in modern history, rivaling the 1918 flu pandemic. Severe …

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike

AR Mehdipour, G Hummer - Proceedings of the National …, 2021 - National Acad Sciences
Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2
(ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the …

Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

B Wang, L Zhang, Y Wang, T Dai, Z Qin… - Signal transduction and …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …