Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …

ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …

Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

Spray drying is a constructive single-step manufacturing technique used to produce dry
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …

With the use of contemporary tools and techniques, it has become possible to more
precisely tune the biochemical mechanisms associated with using nonviral vectors for gene …

Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules
and biologics and offer several advantages for inhaled therapy. Early DPI products were …

Synthetic polymers have enabled amorphous solid dispersions (ASDs) to emerge as an oral
delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD …

In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …

Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …