Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic
lysis, resulting in cytomembrane rupture and release of immunostimulatory components …

The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …

Background: Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and
accounts for the fourth common cause of cancer-related deaths. Recently, pyroptosis has …

Background Despite tremendous advances in cancer research, breast cancer (BC) remains
a major health concern and is the most common cancer affecting women worldwide. Breast …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune
systems, significantly influencing various physiological processes such as cell proliferation …

Mercury (Hg) is a serious metal environmental pollutant. HgCl 2 exposure causes
pyroptosis. When macrophages are severely stimulated, they often undergo M1 polarization …

Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

DEAD-box (DDX) 5 and DDX17, which belong to the DEAD-box RNA helicase family, are
nuclear and cytoplasmic shuttle proteins. These proteins are expressed in most tissues and …

The tumor immune microenvironment (TIME) plays a key role in immunosuppression in
cancer, which results in tumorigenesis and tumor progression, and contributes to …