Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

Insulin-like growth factors (IGFs) bind specifically to the IGF1 receptor on the cell surface of
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …

Growth hormone (GH) research and its clinical application for the treatment of growth
disorders span more than a century. During the first half of the 20th century, clinical …

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

In this article we review the cellular and molecular mechanisms of gastric ulcer healing. A
gastric ulcer (GU) is a deep defect in the gastric wall penetrating through the entire mucosa …

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for
Pathogenesis* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …