Abstract This 2023 Clinical Practice Guideline provides the biomedical definition of death
based on permanent cessation of brain function that applies to all persons, as well as …

A series of landmark experiments conducted throughout the 20th century progressively
localized the regions involved in consciousness to the reticular activating system (RAS) and …

Purpose Ancillary tests are frequently used in death determination by neurologic criteria
(DNC), particularly when the clinical neurologic examination is unreliable. Nevertheless …

Clarity regarding the biomedical definition of death and the criteria for its determination is
critical to inform practices in clinical care, medical research, law, and organ donation. While …

Background and Objectives There is a paucity of data on the frequency and prognosis of
infratentorial brain injury among patients suspected of death by neurologic criteria (DNC) …

There are two anatomic formulations of death by neurologic criteria accepted worldwide:
whole-brain death and brainstem death. As part of the Canadian Death Definition and …

Background Demand for organs exceeds the number of transplants available, underscoring
the need to optimize organ donation procedures. However, protocols for determining brain …

Background: There is international variability in whether neurological determination of death
(NDD) is conceptually defined based on permanent loss of brainstem function or “whole …

Purpose Agitation is a common behavioural problem following traumatic brain injury (TBI).
Intensive care unit (ICU) physicians' perspectives regarding TBI-associated agitation are …

There is robust international consensus that death by neurologic criteria is the “complete
and permanent loss of brain function as defined by an unresponsive coma with loss of …