The microbiome and inflammatory bowel disease

KL Glassner, BP Abraham, EMM Quigley - Journal of Allergy and Clinical …, 2020 - Elsevier
Inflammatory bowel disease (IBD) is a chronic immune-mediated disease affecting the
gastrointestinal tract. IBD consists of 2 subtypes: ulcerative colitis and Crohn disease. IBD is …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases

ML Richard, H Sokol - Nature Reviews Gastroenterology & Hepatology, 2019 - nature.com
The gut microbiota is a dense and diverse ecosystem that is involved in many physiological
functions as well as in disease pathogenesis. It is dominated by bacteria, which have been …

Human genetic variation and the gut microbiome in disease

AB Hall, AC Tolonen, RJ Xavier - Nature Reviews Genetics, 2017 - nature.com
Taxonomic and functional changes to the composition of the gut microbiome have been
implicated in multiple human diseases. Recent microbiome genome-wide association …

Fungal microbiota dysbiosis in IBD

H Sokol, V Leducq, H Aschard, HP Pham, S Jegou… - Gut, 2017 - gut.bmj.com
Objective The bacterial intestinal microbiota plays major roles in human physiology and
IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the …

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

F Imhann, AV Vila, MJ Bonder, J Fu, D Gevers… - Gut, 2018 - gut.bmj.com
Objective Patients with IBD display substantial heterogeneity in clinical characteristics. We
hypothesise that individual differences in the complex interaction of the host genome and …

Gut microbiota beyond bacteria—mycobiome, virome, archaeome, and eukaryotic parasites in IBD

M Matijašić, T Meštrović, H Čipčić Paljetak… - International journal of …, 2020 - mdpi.com
The human microbiota is a diverse microbial ecosystem associated with many beneficial
physiological functions as well as numerous disease etiologies. Dominated by bacteria, the …

[HTML][HTML] Experimental models of inflammatory bowel diseases

P Kiesler, IJ Fuss, W Strober - Cellular and molecular gastroenterology and …, 2015 - Elsevier
The understanding of the intestinal inflammation occurring in the inflammatory bowel
diseases (IBD) has been immeasurably advanced by the development of the now numerous …

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

B Lamas, ML Richard, V Leducq, HP Pham… - Nature medicine, 2016 - nature.com
Complex interactions between the host and the gut microbiota govern intestinal homeostasis
but remain poorly understood. Here we reveal a relationship between gut microbiota and …

Interactions between intestinal microbiota and host immune response in inflammatory bowel disease

M Zhang, K Sun, Y Wu, Y Yang, P Tso… - Frontiers in …, 2017 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic …