Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

The endoplasmic reticulum (ER) stress is an essential step in the progression of brain
ischemia/reperfusion (I/R) injury. It is possible that the timing of events for ER stress …

It is well recognized that mandibular growth, which is caused by a variety of functional
appliances, is considered to be the result of both neuromuscular and skeletal adaptations …

Recent reports considered that it was the disturbance of calcium homeostasis and the
accumulation of misfolded proteins in the endoplasmic reticulum (ER) that activated hepatic …

Colorectal cancer (CRC) is one of the most common malignant neoplasms with high
mortality worldwide. Oridonin, a diterpenoid isolated from the Chinese medicinal herb …

Oridonin has attracted considerable attention in the last decade because of its anti-cancer
pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb …

Gastric cancer is among the leading causes of cancer-related deaths worldwide. While
heritable forms of gastric cancer are relatively rare, identifying the genes responsible for …

Background MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in
patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway …

Targeting endoplasmic reticulum (ER) stress presents a promising strategy in cancer
therapy. We previously reported a series of 1, 2, 4-oxadiazole derivatives that induced the …

Hormesis is an adaptive response to a variety of oxidative stresses that renders cells
resistant to harmful doses of stressing agents. Caffeic acid (CaA) is an important antioxidant …