An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Advances in predicting subcellular localization of multi-label proteins and its implication for developing multi-target drugs
KC Chou - Current medicinal chemistry, 2019 - ingentaconnect.com
The smallest unit of life is a cell, which contains numerous protein molecules. Most of the
functions critical to the cell's survival are performed by these proteins located in its different …
functions critical to the cell's survival are performed by these proteins located in its different …
[HTML][HTML] pLoc-mEuk: Predict subcellular localization of multi-label eukaryotic proteins by extracting the key GO information into general PseAAC
X Cheng, X Xiao, KC Chou - Genomics, 2018 - Elsevier
Many efforts have been made in predicting the subcellular localization of eukaryotic
proteins, but most of the existing methods have the following two limitations:(1) their …
proteins, but most of the existing methods have the following two limitations:(1) their …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
StackCPPred: a stacking and pairwise energy content-based prediction of cell-penetrating peptides and their uptake efficiency
Abstract Motivation Cell-penetrating peptides (CPPs) are a vehicle for transporting into living
cells pharmacologically active molecules, such as short interfering RNAs, nanoparticles …
cells pharmacologically active molecules, such as short interfering RNAs, nanoparticles …
[HTML][HTML] pLoc-mGneg: Predict subcellular localization of Gram-negative bacterial proteins by deep gene ontology learning via general PseAAC
X Cheng, X Xiao, KC Chou - Genomics, 2018 - Elsevier
Abstract Information of the proteins' subcellular localization is crucially important for
revealing their biological functions in a cell, the basic unit of life. With the avalanche of …
revealing their biological functions in a cell, the basic unit of life. With the avalanche of …
[HTML][HTML] iRSpot-Pse6NC: Identifying recombination spots in Saccharomyces cerevisiae by incorporating hexamer composition into general PseKNC
Meiotic recombination caused by meiotic double-strand DNA breaks. In some regions the
frequency of DNA recombination is relatively higher, while in other regions the frequency is …
frequency of DNA recombination is relatively higher, while in other regions the frequency is …
pLoc_bal-mAnimal: predict subcellular localization of animal proteins by balancing training dataset and PseAAC
Motivation A cell contains numerous protein molecules. One of the fundamental goals in cell
biology is to determine their subcellular locations, which can provide useful clues about their …
biology is to determine their subcellular locations, which can provide useful clues about their …
DBP-CNN: Deep learning-based prediction of DNA-binding proteins by coupling discrete cosine transform with two-dimensional convolutional neural network
To improve the prediction of DNA-binding Proteins (DBPs), this paper presents a deep
learning-based method, named DBP-CNN. To efficiently extract the important features, we …
learning-based method, named DBP-CNN. To efficiently extract the important features, we …
[HTML][HTML] pLoc_bal-mGpos: predict subcellular localization of Gram-positive bacterial proteins by quasi-balancing training dataset and PseAAC
X Xiao, X Cheng, G Chen, Q Mao, KC Chou - Genomics, 2019 - Elsevier
Abstract Knowledge of protein subcellular localization is vitally important for both basic
research and drug development. With the avalanche of protein sequences emerging in the …
research and drug development. With the avalanche of protein sequences emerging in the …