Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Focal iron accumulation associated with brain iron dyshomeostasis is a pathological
hallmark of various neurodegenerative diseases (NDD). The application of iron-sensitive …

An urgent need for efficacious disease-modifying therapies is required to slow down
Parkinson's disease (PD) progression. Iron is required as a cofactor in metabolic processes …

No disease modifying drugs have been approved for Alzheimer's disease despite recent
major investments by industry and governments throughout the world. The burden of …

As the most abundant marine carotenoid extracted from seaweeds, fucoxanthin (FUC) is
considered to have excellent neuroprotective activity. However, the target of FUC for its …

Iron plays an essential role in all living cells because of its unique chemical properties. It is
also the most abundant trace element in mammals. However, when iron is present in excess …

Gallic acid is one of the most important polyphenolic compounds, which is considered an
excellent free radical scavenger. 6-Hydroxydopamine (6-OHDA) is a neurotoxin, which has …

Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …

Iron plays a vital role in several cellular functions due to its unique physiochemical
properties. Iron concentration increases in the brain with age due to multiple factors …

The present review reports a list of approximately 800 compounds which have been used,
tested or proposed for Parkinson's disease (PD) therapy in the year range 2014–2019 …