Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle
macromolecules and organelles. It plays a critical role in removing protein aggregates, as …

In the 20 years since the discovery of the first mutation linked to familial hypertrophic
cardiomyopathy (HCM), an astonishing number of mutations affecting numerous sarcomeric …

Cardiomyocyte hypertrophy differs according to the stress exerted on the myocardium. While
pressure overload‐induced cardiomyocyte hypertrophy is associated with depressed …

Rationale: Understanding the molecular mechanisms of deleterious cardiac remodeling is
important for the development of treatments for heart failure. Recent studies have …

Significance: Antineoplastic therapies have significantly improved the prognosis of oncology
patients. However, these treatments can bring to a higher incidence of side-effects, including …

The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral
to the development of the cardiovascular system and cardiovascular diseases. The UPS …

The heart is constantly under mechanical, metabolic, and thermal stress, even at baseline
physiological conditions, and cardiac stress may increase as a result of environmental or …

Our understanding of genes that cause skeletal muscle disease has increased
tremendously over the past three decades. Advances in approaches to genetics and …

Rationale: Previous studies have suggested that myocardial inflammation plays a critical
role after ischemic myocardial infarction (MI); however, the underlying mechanisms still need …

Rationale: A delicate balance between protein synthesis and degradation maintains cardiac
size and function. TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle …