Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention

CL Holmes, OR Albin, HLT Mobley… - Nature Reviews …, 2024 - nature.com
Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

TJ Kochan, SH Nozick, RL Medernach… - BMC infectious …, 2022 - Springer
Background Klebsiella pneumoniae strains have been divided into two major categories:
classical K. pneumoniae, which are frequently multidrug-resistant and cause hospital …

Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy

MJ Martin, BW Corey, F Sannio… - Proceedings of the …, 2021 - National Acad Sciences
A protracted outbreak of New Delhi metallo-β-lactamase (NDM)–producing carbapenem-
resistant Klebsiella pneumoniae started in Tuscany, Italy, in November 2018 and continued …

[HTML][HTML] Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae: Key virulence factors and evolutionary convergence

T Chen, L Ying, L Xiong, X Wang, P Lu, Y Wang… - hLife, 2024 - Elsevier
The emergence of hypervirulence (hv) and carbapenem resistance (CR) as distinct
evolutionary directions for Klebsiella pneumoniae presents a significant threat in clinical …

Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection

J Vornhagen, EK Roberts, L Unverdorben… - Nature …, 2022 - nature.com
Members of the Klebsiella pneumoniae species complex frequently colonize the gut and
colonization is associated with subsequent infection. To identify genes associated with …

The Klebsiella pneumoniae ter Operon Enhances Stress Tolerance

S Mason, J Vornhagen, SN Smith, LA Mike… - Infection and …, 2023 - Am Soc Microbiol
Healthcare-acquired infections are a leading cause of disease in patients that are
hospitalized or in long-term-care facilities. Klebsiella pneumoniae (Kp) is a leading cause of …

Whole Genome Sequencing Reveals High Genetic Diversity, Diverse Repertoire of Virulence-Associated Genes and Limited Antibiotic Resistance Genes among …

DK Byarugaba, G Wokorach, S Alafi, B Erima… - Microorganisms, 2023 - mdpi.com
Commensal Escherichia coli with broad repertoire of virulence and antimicrobial resistance
(AMR) genes pose serious public health risks as reservoirs of AMR and virulence. This study …

Characterization of the Tellurite-Resistance Properties and Identification of the Core Function Genes for Tellurite Resistance in Pseudomonas citronellolis SJTE-3

W Peng, Y Wang, Y Fu, Z Deng, S Lin, R Liang - Microorganisms, 2022 - mdpi.com
Tellurite is highly toxic to bacteria and commonly used in the clinical screening for
pathogens; it is speculated that there is a potential relationship between tellurite resistance …

Hypervirulent Klebsiella pneumoniae employs genomic island encoded toxins against bacterial competitors in the gut

YH Tan, P Arros, C Berríos-Pastén, I Wijaya… - The ISME …, 2024 - academic.oup.com
The hypervirulent lineages of Klebsiella pneumoniae (HvKp) cause invasive infections such
as Klebsiella-liver abscess. Invasive infection often occurs after initial colonization of the …

Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS/NF-κB signal pathway in chickens

H Yujiao, T Xinyu, F Xue, L Zhe, P Lin, S Guangliang… - Biometals, 2023 - Springer
Selenium (Se) is an essential trace element for the body. Various organs of the body,
including the intestine, are affected by its deficiency. Se deficiency can induce oxidative …