The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

Vertebrate genomes are mosaics of isochores--namely, of long (> 300 kb), compositionally
homogeneous DNA segments that can be subdivided into a small number of families …

The term genome was first introduced by German botanist Hans Winkler in the early 19th
century to describe the eukaryotic chromosome. It gained considerable attention through the …

DNA melting is rate-limiting for cytosine deamination, from which we infer that the rate of
cytosine deamination should decline twofold for each 10% increase in GC content. Analysis …

Linear correlations exist between the GC levels of third codon positions (GC3) of individual
human genes and the GC levels of long genomic sequences and DNA molecules (50–100 …

Background: Nucleotide substitution rates and G+ C content vary considerably among
mammalian genes. It has been proposed that the mammalian genome comprises a mosaic …

This review will first present some properties (including compositional pattern, correlations
between isochores and chromosomal bands, and gene distribution) of the human genome …

Understanding the complex organization of genomes as well as predicting the location of
genes and the possible structure of the gene products are some of the most important …

Analytical DNA ultracentrifugation revealed that eukaryotic genomes are mosaics of
isochores: long DNA segments (≫ 300 kb on average) relatively homogeneous in G+ C …

Duchenne muscular dystrophy (DMD) is caused by X-linked inherited or de novo DMD gene
mutations predominantly affecting males who develop early-onset muscle degeneration …